Assistant professor   田村 朋則 - Tomonori Tamura -

Paper List

Article

24. Enhanced Suppression of a Protein–Protein Interaction in Cells Using Small-Molecule Covalent Inhibitors Based on an N-Acyl-N-alkyl Sulfonamide Warhead
Tsuyoshi Ueda, Tomonori Tamura, Masaharu Kawano, Keiya Shiono, Fruzsina Hobor, Andrew J. Wilson, and Itaru Hamachi*
Journal of the American Chemical Society , 143 (2021) doi:10.1021/jacs.1c00703

23. Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent
Vikram Thimaradka, Jae Hoon Oh, Christina Heroven, A. Radu Aricescu, Michisuke Yuzaki, Tomonori Tamura*, Itaru Hamachi*
Bioorganic & Medicinal Chemistry , 30, 115947 (2021) doi:10.1016/j.bmc.2020.115947

22. Organelle membrane-specific chemical labeling and dynamic imaging in living cells
Tomonori Tamura, Alma Fujisawa, Masaki Tsuchiya, Yuying Shen, Kohjiro Nagao, Shin Kawano, Yasushi Tamura, Toshiya Endo, Masato Umeda & Itaru Hamachi*
Nature Chemical Biology ,16, 12, 1361-1367 (2020) doi: 10.1038/s41589-020-00651-z

21. Imaging and profiling of proteins under oxidative conditions in cells and tissues by hydrogen-peroxide-responsive labeling
Hao Zhu, Tomonori Tamura, Alma Fujisawa, Yuki Nishikawa, Rong Cheng, Mikiko Takato, and Itaru Hamachi*
Journal of the American Chemical Society , 142, 37, 15711–15721(2020)  doi:10.1021/jacs.0c02547

20. Development of a Photoactivatable Proximity Labeling Method for the Identification of Nuclear Proteins
Tomonori Tamura*, Mikiko Takato, Keiya Shiono, Itaru Hamachi*
Chemistry Letters , 49, 145-148 (2020) doi:10.1246/cl.190804

19. Development of a cell-based ligand-screening system for identifying Hsp90 inhibitors
Tsuyoshi Ueda, Tomonori Tamura*, Itaru Hamachi*
Biochemistry , 59, 2, 179-182 (2020) doi:10.1021/acs.biochem.9b00781

18. Development of a nitric oxide-responsive labeling reagent for proteome analysis of live cells
Yuki Nishikawa, Takayuki Miki, Masashi Awa, Keiko Kuwata, Tomonori Tamura, Itaru Hamachi
ACS Chemical Biology , 14, 3, 397–404 (2019) doi: 10.1021/acschembio.8b01021

17. Selective and reversible modification of kinase cysteines with chlorofluoroacetamides
Naoya Shindo, Hirokazu Fuchida, Mami Sato, Kosuke Watari, Tomohiro Shibata, Keiko Kuwata, Chizuru Miura, Kei Okamoto, Yuji Hatsuyama, Keisuke Tokunaga, Seiichi Sakamoto, Satoshi Morimoto, Yoshito Abe, Mitsunori Shiroishi, Jose M. M. Caaveiro, Tadashi Ueda, Tomonori Tamura, Naoya Matsunaga, Takaharu Nakao, Satoru Koyanagi, Shigehiro Ohdo, Yasuchika Yamaguchi, Itaru Hamachi, Mayumi Ono and Akio Ojida
Nature Chemical Biology (2019)  doi: 10.1038/s41589-018-0204-3

16. Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems
Tomonori Tamura, Itaru Hamachi
Journal of the American Chemical Society, 141, 7, 2782–2799 (2019)  doi: 10.1021/jacs.8b11747

15. Chemical profiling of the endoplasmic reticulum proteome using designer labeling reagents
Alma Fujisawa, Tomonori Tamura, Yuki Yasueda, Keiko Kuwata, Itaru Hamachi
Journal of the American Chemical Society, 140, 49, 17060-17070(2018)

14. Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide.
Tomonori Tamura, Tsuyoshi Ueda, Taiki Goto, Taku Tsukidate, Yonatan Shapira, Yuki Nishikawa, Alma Fujisawa, Itaru Hamachi
Nature Communications, 9, 1870 (2018)

13. Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding live cells.
Kazuma Amaike, Tomonori Tamura, Itaru Hamachi
Chem. Commun. Feature Article, 53, 11972-11983 (2017)

12. Affinity-guided oxime chemistry for selective protein acylation in live tissue systems.
Tomonori Tamura, Zhining Song, Kazuma Amaike, Shin Lee, Sifei Yin, Shigeki Kiyonaka, Itaru Hamachi
J. Am. Chem. Soc., 139, 14181-14191 (2017)

11. A set of organelle-localizable reactive molecules for mitochondrial chemical proteomics in living cells and brain tissues.
Yuki Yasueda, Tomonori Tamura, Alma Fujisawa, Keiko Kuwata, Shinya Tsukiji, Shigeki Kiyonaka, Itaru Hamachi
J. Am. Chem. Soc., 138, 7592-7602 (2016)

10. Nucleus-selective Chemical Proteomics Using Hoechst-tagged Reactive Molecules.
Yuki Yasueda, Tomonori Tamura, Itaru Hamachi
Chem. Lett., 45, 265-267 (2016)

9. Biomembrane-embedded catalysts for membrane-associated protein labeling on red blood cells.
Yuki Yasueda, Tomonori Tamura, Keiko Kuwata, Yousuke Takaoka, Itaru Hamachi
Chem. Lett., 44, 1673-1675 (2015)

8. Analysis of cell-surface receptor dynamics through covalent labeling by catalyst-tethered antibody.
Takahiro Hayashi, Yuki Yasueda, Tomonori Tamura, Yousuke Takaoka, Itaru Hamachi
J. Am. Chem. Soc., 137, 3360-3365 (2015)

7. Extended affinity-guided DMAP chemistry with finely-tuned acyl donor for intracellular FKBP12 labeling.
Zhining Song, Yousuke Takaoka, Yoshiyuki Kioi, Kazuhiro Komatsu, Tomonori Tamura, Takayuki Miki, Itaru Hamachi
Chem. Lett., 44, 333-335 (2015)

6. Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry.
Kei Yamaura, Keiko Kuwata, Tomonori Tamura, Yoshiyuki Kioi, Yousuke Takaoka, Shigeki Kiyonaka, Itaru Hamachi
Chem. Commun., 50, 14097-14100
 (2014)

5. Semisynthetic lectin−4-dimethylaminopyridine conjugates for labeling and profiling glycoproteins on live cell surfaces.
Takahiro Hayashi, Yedi Sun, Tomonori Tamura, Keiko Kuwata, Zhining Song, Yousuke Takaoka, Itaru Hamachi
J. Am. Chem. Soc., 135, 12252-12258 (2013)

4. Fluorophore labeling of native FKBP12 by ligand-directed tosyl chemistry allows detection of its molecular interactions in vitro and in living cells.
Tomonori Tamura, Yoshiyuki Kioi, Takayuki Miki, Shinya Tsukiji, Itaru Hamachi
J. Am. Chem. Soc., 135, 6782-6785 (2013)

3. Native FKBP12 engineering by ligand-directed tosyl chemistry: labeling properties and application to photo-cross-linking of protein complexes in vitro and in living cells.
Tomonori Tamura, Shinya Tsukiji, Itaru Hamachi
J. Am. Chem. Soc., 134, 2216-2226 (2012)

2. Quenched ligand-directed tosylate reagents for one-Step construction of turn-on fluorescent biosensors.
Shinya Tsukiji, Hangxiang Wang, Masayoshi Miyagawa, Tomonori Tamura, Yousuke Takaoka, Itaru Hamachi
J. Am. Chem. Soc., 131, 9046-9054 (2009)

1. Ligand-directed tosyl chemistry for protein labeling in vivo.
Shinya Tsukiji, Masayoshi Miyagawa, Yousuke Takaoka, Tomonori Tamura, Itaru Hamachi
Nat. Chem. Biol., 5, 341-343 (2009)

Review

12. Organelle-selective labeling of choline-containing phospholipids(CPLs) and real-time imaging in living cells
Masaki Tsuchiya, Tomonori Tamura, Itaru Hamachi*
Current Protocols, e105, Volume 1 (2021) doi: 10.1002/cpz1.105

11. Chemical Tools for Endogenous Protein Labeling and Profiling
Kazuki Shiraiwa, Rong Cheng, Hiroshi Nonaka, Tomonori Tamura, and Itaru Hamachi*
Cell Chemical Biology, 27, 8, 970-985(2020) doi:10.1016/j.chembio|.2020.06016

10. Chemical Proteomics for Subcellular Proteome Analysis
Hao Zhu, Tomonori Tamura, Itaru Hamachi
Current opinion in chemical biology, 48, 1-7 (2019)

9. Molecular Technologies in Life Innovation:Novel Molecular Technologies for Labeling and Functional Control of Proteins Under Live Cell Conditions
Itaru Hamachi, Shigeki Kiyonaka, Tomonori Tamura, Ryou Kubota
Molecular Technology vol.2, 297-328 (2018)

8. In situ Construction of Protein-based Semisynthetic Biosensors.
Tsuyoshi Ueda, Tomonori Tamura, Itaru Hamachi
ACS Sensors, 3, 527-539 (2018)

7. In Situ Protein Labeling in Complex Environments.
Tomonori Tamura, Hajime Shigemitsu, Itaru Hamachi
Comprehensive Supramolecular Chemistry II, 409–437. Oxford: Elsevier. (2017)

6. リガンド指向性NASA化学による高速蛋白質ラベリングとコバレントドラッグへの展開
田村朋則
生体機能関連化学部会 NEWS LETTER, 32, 3, 8-12 (2017)

5. 生細胞における細胞内局在特異的分子標識法
藤沢有磨、田村朋則、浜地格
生体の科学, 68, 428-429 (2017)

4. タンパク質有機化学の進歩と生細胞への展開
西川雄貴、田村朋則、浜地格
有機合成化学協会誌, 74, 521-531 (2016)

3. Labeling proteins by affinity-guided DMAP chemistry.
Tomonori Tamura, Itaru Hamachi
Methods in Molecular Biology, 1266, 229-242 (2015)

2. Recent progress in design of protein-based fluorescent biosensors and their cellular applications.
Tomonori Tamura, Itaru Hamachi
ACS Chemical Biology, 9, 2708-2717 (2014)

1. 内在性タンパク質に対する選択的ケミカルラベリングの新手法: リガンド指向型トシル化学によるラベル化の可能性
田村朋則、浜地格
化学と生物, 48, 160-162 (2010)


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