Associate professor [ERATO]   野中 洋 - Hiroshi Nonaka -


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38. H. Nonaka, T. Mino, S. Sakamoto, J. H. Oh, Y. Watanabe, M. Ishikawa, A. Tsushima, K. Amaike, S. Kiyonaka, T. Tamura, A. R. Aricescu, W. Kakegawa, E. Miura, M. Yuzaki, I. Hamachi
" Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes"
Chem, in press (2022).

37. K. Ojima, W. Kakegawa, T. Yamasaki, Y. Miura, M. Itoh, Y. Michibata, R. Kubota, T. Doura, E. Miura, H. Nonaka, S. Mizuno, S. Takahashi, M. Yuzaki*, I. Hamachi*, S. Kiyonaka*
" Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue"
Nature Communications, 13, 3167 (2022).

36. Y. Kondo, A. E. Elhelaly, F. Hyodo, T. Nishihara, M. Itoda, H. Nonaka, M. Matsuoc, S. Sando
" Evaluation of enzymatic and magnetic properties of gamma-glutamyl-[1-C-13]glycine and its deuteration toward longer retention of the hyperpolarized state"
RSC ADVANCES, 11, 59, 37011-37018 (2021) .

35. T. Ota, A. Senoo, M. Shirakawa, H. Nonaka, Y. Saito, S. Ito, G. Ueno, S. Nagatoishi, K. Tsumoto, S. Sando*
" Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate"
iScience, 2, 102036 (2021).

34. A. Radaelli, H. A. Yoshihara, H. Nonaka, S. Sando, J. H. Ardenkjaer-Larsen, R. Gruetter, A. Capozzi*
"13C Dynamic Nuclear Polarization using SA-BDPA at 6.7 T and 1.1 K: Coexistence of Pure Thermal Mixing and Well-Resolved Solid Effect"
J. Phys. Chem. Lett., 11, 6873-6879 (2020).

33. K Tateishi*, M Negoro, H Nonaka, A Kagawa, S Sando, S Wada, M Kitagawa, T Uesaka
"Dynamic nuclear polarization with photo-excited triplet electrons using 6,13-diphenylpentacene"
Phys. Chem. Chem. Phys., 21, 19737-19741 (2019).

32. M. Itoda, Y. Naganawa*, M. Ito, H. Nonaka, S. Sando*
"Structural exploration of rhodium catalysts and their kinetic studies for efficient parahydrogen-induced polarization by side arm hydrogenation"
RSC Advances, 9, 18183-18190 (2019).

31. H. Nonaka,* Y. Nakanishi, S. Kuno, T. Ota, K. Mochidome, Y. Saito, F. Sugihara, Y. Takakusagi, I. Aoki, S. Nagatoishi, K. Tsumoto, S. Sando*
"Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction"
Nat. Commun., 10, 876 (2019).

30. T. Nishihara,* S. Kuno, H. Nonaka, S. Tabata, N. Saito, S. Fukuda, M. Tomita, S. Sando, T. Soga*
"Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection"
Chem. Commun., 54, 11745–11748 (2018).

29. Y. Imakura, H. Nonaka*, Y. Takakusagi, K. Ichikawa, N. R. Maptue, A. M. Funk, C. Khemtong, S. Sando*
"Rational Design of [13C, D14] Tert-butylbenzene as a Scaffold Structure for Designing Long-lived Hyperpolarized 13C Probes"
Chem. Asian J., 13, 280–283 (2018).

28. T. Nishihara, Y. Kameyama, H. Nonaka, Y. Takakusagi, F. Hyodo, K. Ichikawa, S. Sando*
"A strategy to design hyperpolarized 13C magnetic resonance probes using [1-13C]α-amino acid as a scaffold structure"
Chem. Asian J., 12, 949–953 (2017).

27. H. Nonaka*, M. Hirano, Y. Imakura, Y. Takakusagi, K. Ichikawa, S. Sando*
"Design of a 15N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State"
Sci. Rep., 7, 40104 (2017).

26. T. Nishihara, H. A.I. Yoshihara, H. Nonaka, Y. Takakusagi, F. Hyodo, K. Ichikawa, E. Can, J. AM Bastiaansen, Y. Takado, A. Comment, S. Sando*
"Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized 13C‐Labeled Molecular Probe"
Angew. Chem. Int. Ed., 55, 10626–10629 (2016).

25. R. Hata, H. Nonaka, Y. Takakusagi, K. Ichikawa, S. Sando*
"Design of a Hyperpolarized Molecular Probe for Detection of Aminopeptidase N Activity"
Angew. Chem. Int. Ed., 55, 1765–1768 (2016).

24. R. Hata, H. Nonaka, Y. Takakusagi, K. Ichikawa, S. Sando*
"Design of a hyperpolarized 15N NMR probe that induces a large chemical-shift change upon binding of calcium ions"
Chem. Commun., 51, 12290–12292 (2015).

23. H. Nonaka, Q. An, F. Sugihara, T. Doura, A. Tsuchiya, Y. Yoshioka, S. Sando*
"Phenylboronic Acid-based 19F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change"
Anal. Sci., 31, 331–335 (2015).

22. T. Nishihara, H. Nonaka, S. Sando*
"Design of Triple-resonance NMR Reporter Assay"
Chem. Lett., 43, 1873–1875 (2014).

21. T. Doura, R. Hata, H. Nonaka, F. Sugihara, Y. Yoshioka, S. Sando*
"Adhesive 19F MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment"
Chem. Commun., 49, 11421–11423 (2013).

20. H. Nonaka, R. Hata, T. Doura, T. Nishihara, K. Kumagai, M. Akakabe, M. Tsuda, K. Ichikawa, S. Sando*
"A platform for designing hyperpolarized magnetic resonance chemical probes"
Nat. Commun., 4, 2411 (2013).

19. S. Uchinomiya, H. Nonaka, S. Wakayama, A. Ojida, I. Hamachi*
"In-Cell Covalent Labeling of Reactive His-Tag Fused Proteins"
Chem. Commun., 49, 5022–5024 (2013).

18. T. Doura, R. Hata, H. Nonaka, K. Ichikawa, S. Sando*
"Design of a 13C Magnetic Resonance Probe Using a Deuterated Methoxy Group as a Long-Lived Hyperpolarization Unit"
Angew. Chem. Int. Ed., 51, 10114–10117 (2012).

17. R. Ueki, K. Yamaguchi, H. Nonaka, S. Sando*
"1H-NMR Probe for In Situ Monitoring of Dopamine Metabolism and Its Application to Inhibitor Screening"
J. Am. Chem. Soc., 134, 12398–12401 (2012).

16. T. Tokunaga, S. Namiki, K. Yamada, T. Imaishi, H. Nonaka, K. Hirose, S. Sando*
"Cell Surface-Anchored Fluorescent Aptamer Sensor Enables Imaging of Chemical Transmitter Dynamics"
J. Am. Chem. Soc., 134, 9561–9564 (2012).

15. T. Nishihara, H. Nonaka, T. Naganuma, K. Ichikawa, S. Sando*
"Mouse Lactate Dehydrogenase X: A Promising Magnetic Resonance Reporter Protein Using Hyperpolarized Pyruvic Acid Derivative Y"
Chem. Sci., 3, 800–806 (2012).

14. T. Doura, H. Nonaka, S. Sando*
"Atom arrangement strategy for designing a turn-on 1H magnetic resonance probe: a dual activatable probe for multimodal detection of hypochlorite"
Chem. Commun., 48, 1565–1567 (2012).

13. S. Fujishima, H. Nonaka, S. Uchinomiya, Y. A. Kawase, A. Ojida, I. Hamachi*
"Design of Multinuclear Zn(II) Complex as New Molecular Probe for Fluorescence Imaging of His-tag Fused Proteins"
Chem. Commun., 48, 594–596 (2012).

12. K. Yamaguchi, R. Ueki, H. Nonaka, F. Sugihara, T. Matsuda, S. Sando*
"Design of Chemical Shift-Switching 19F MRI Probe for the Specific Detection of Human Monoamine Oxidase A"
J. Am. Chem. Soc., 133, 14208–14211 (2011).

11. H. Wang, Y. Koshi, D. Minato, H. Nonaka, S. Kiyonaka, Y. Mori, S. Tsukiji, I. Hamachi*
"Chemical Cell-Surface Receptor Engineering Using Affinity-Guided, Multivalent Organocatalysts"
J. Am. Chem. Soc., 133, 12220–12228 (2011).

10. K. Yamaguchi, R. Ueki, H. Yamada, Y. Aoyama, H. Nonaka, S. Sando*
"In situ analysis of [8-13C-7-15N]-double-labelled theophylline by triple resonance NMR technique"
Anal. Methods, 3, 1664–1666 (2011).

9. M. Bhuyan, E. Katayev, S. Stadlbauer, H. Nonaka, A. Ojida, I. Hamachi, B. König*
"Rigid Luminescent Bis-Zinc(II)–Bis-Cyclen Complexes for the Detection of Phosphate Anions and Non-Covalent Protein Labeling in Aqueous Solution"
Eur. J. Org. Chem. 15, 2807–2817 (2011).

8. H. Nonaka, S. Fujishima, S. Uchinomiya, A. Ojida, I. Hamachi*
"Selective Covalent Labeling of Tag-Fused GPCR Proteins on Live Cell Surface with a Synthetic Probe for Their Functional Analysis"
J. Am. Chem. Soc., 132, 9301–9309 (2010).

7. A. Ojida, S. Fujishima, K. Honda, H. Nonaka, S. Uchinomiya, I. Hamachi*
"Binuclear Ni(II)-DpaTyr Complex as a High Affinity Probe for an Oligo-Aspartate Tag Tethering to Proteins"
Chem. Asian J., 4, 877–886 (2010).

6. H. Nonaka, S. Fujishima, S. Uchinomiya, A. Ojida, I. Hamachi*
"FLAG-tag selective covalent protein labeling via a binding-induced acyl-transfer reaction"
Bioorg. Med. Chem. Lett., 19, 6696–6699 (2009).

5. S. Uchinomiya, H. Nonaka, S. Fujishima, A. Ojida, I. Hamachi*
"Site-Specific Covalent Labeling of His-tag Fused Proteins with a Reactive Ni(II)-NTA Probe"
Chem. Commun., 39, 5880–5882 (2009).

4. T. Kohira, I. Takashima, H. Nonaka, A. Ojida, I. Hamachi*
"Real-time Off/On-mode Fluorescence Assay for Enzyme Reactions Involving Nucleoside Polyphosphates by Use of a Xanthene ZnII-Dpa Chemosensor"
Chem. Lett., 37, 1164–1165 (2008).

3. A. Ojida, I. Takashima, T. Kohira, H. Nonaka, I. Hamachi*
"Turn-On Fluorescence Sensing of Nucleoside Polyphosphates Using a Xanthene-Based Zn(II) Complex Chemosensor"
J. Am. Chem. Soc., 130, 12095–12101 (2008).

2. H. Nonaka, S. Tsukiji, A. Ojida, I. Hamachi*
"Non-enzymatic Covalent Protein Labeling Using a Reactive Tag"
J. Am. Chem. Soc., 129, 15777–15779 (2007).

1. A. Ojida, H. Nonaka, Y. Miyahara, S. Tamaru, K. Sada, I. Hamachi*
"Bis(Dpa-Zn(II)) Appended Xanthone: Excitation Ratiometric Chemosensor for Phosphate Anion Derivatives Based on Anion-Induced Rearragement of Coordination Chemostry"
Angew. Chem. Int. Ed., 45, 5518–5521(2006).


9. Design of Nuclear Magnetic Resonance Molecular Probes for Hyperpolarized Bioimaging
Y. Kondo, H. Nonaka, Y. Takakusagi, S. Sando*
Angew. Chem. Int. Ed., 60, 27, 14779 (2021).

8. Chemical tools for endogenous protein labeling and profiling
K. Shiraiwa, R. Cheng, H. Nonaka, T. Tamura, I. Hamachi*
Cell Chemical Biology, 27, 8, 970-985(2020).

7. 動的核偏極法を利用した高感度核磁気共鳴分子プローブの設計
化学と工業 “飛翔する若手研究者”, 日本化学会, 71, 692–693 (2018).

6. Molecular Technology for Highly Sensitive Biomolecular Analysis: Hyperpolarized NMR/MRI Probes Shinsuke
Sando, Hiroshi Nonaka
Molecular Technology - Life Innovation, Wiley, in press.

5. 長時間解析を可能とする核偏極分子プローブの開発
JSMI Report, 10, 3–7 (2017).

4. 革新的な核磁気共鳴イメージング -核超偏極を利用した高感度個体解析-
化学, 68, 66–67 (2013).

3. 高選択的・高感度な核磁気共鳴プローブ分子
蛍光イメージング/MRIプローブの開発, 127–136 (2011).

2. 小分子プローブを用いたタンパク質ラベル化法の新展開
バイオサイエンスとインダストリー, 3, 194–197 (2010).

1. 人工機能化タンパク質による蛍光イメージング
別冊化学 分子イメージング, 37–42 (2007).

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