メンバー

東口　顕士　(Dr. HIGASHIGUCHI Kenji)

京都大学大学院工学研究科
合成・生物化学専攻　講師
（物理有機化学分野 松田研究室)

Tel: 075-383-2745
Fax: 075-383-2741
居室: A4棟3階　324号室

新学術領域研究 領域略称「発動分子科学」
第二期　B01班 公募研究

（終了課題）
科学技術振興機構 戦略的創造研究推進事業 さきがけ (JST PRESTO)
「分子技術と新機能創出」領域
「超分子構造体の光誘起形態変化と光駆動物質輸送」

（終了課題）
新学術領域研究 領域略称「融合マテリアル」
第二期　A01班 公募研究
第一期　A01班 公募研究

略歴

原著論文

1. NIR-Responsive Double Closed-Ring Isomer of a Diarylethene Fused Dimer Synthesized by Stepwise Photochemical and Oxidative Cyclization Reaction
   K. Satake, N. Ootsuki, K. Higashiguchi,* K. Matsuda*
   J. Am. Chem. Soc. 2025, 147(11), 9653–9664. (2025.3)
   Doi: Doi: 10.1021/jacs.4c17757
2. Lysine-Reactive N-Acyl-N-aryl Sulfonamide Warheads: Improved Reaction Properties and Application in the Covalent Inhibition of an Ibrutinib-Resistant BTK Mutant
   M. Kawano, S. Murakawa, K. Higashiguchi, K. Matsuda, T. Tamura*, I. Hamachi*
   J. Am. Chem. Soc. 2023, 145(48), 26202–26212. (2023.11)
   Doi: 10.1021/jacs.3c08740
3. Kinetic Analysis of the Photochemical Paths in Asymmetric Diarylethene Dimer
   Y. Hiroyasu, K. Higashiguchi*, C. Shirakata, M. Sugimoto, K. Matsuda*
   Chem. Eur. J. 2023, e202300126. (2023.5)
   Doi: 10.1002/chem.202300126
4. Boosting Visible Light-Induced Photocyclization Quantum Yield of a Diarylethene-Perylenebisimide Dyad by Introducing a Ketone Spacer Group
   I. Ikariko, S. Kim, Y. Hiroyasu, K. Higashiguchi, K. Matsuda, S. Yokojima, S. Kurihara, T. Fukaminato*
   Chem. Lett. 2022, 51(11), 1095-1098. (2022.9)
   Doi: 10.1246/cl.220404
5. All Visible (> 500 nm) Light-Induced Diarylethene Photochromism based on Multiplicity Conversion via Intramolecular Energy Transfer
   I. Ikariko, S. Kim, Y. Hiroyasu, K. Higashiguchi, K. Matsuda, T. Hirose, H. Sotome, H. Miyasaka, S. Yokojima, M. Irie, S. Kurihara, T. Fukaminato*
   J. Phys. Chem. Lett. 2022, 13(32), 7429-7436. (2022.7)
   Doi: 10.1021/acs.jpclett.2c01903
6. Sheet-Like Supramolecular Assembly of Amphiphilic Diarylethene Showing Photoinduced Transformation Formed by Depletion Force
   H. Yasuda, K. Higashiguchi*, K. Matsuda*
   Chem. Lett. 2021, 50, 1875-1878. (2021.8)
   Doi: Doi: 10.1246/cl.210452
7. Re-entrant Photoinduced Morphological Transformation and Temperature‐Dependent Kinetic Products of a Rectangular‐Shaped Amphiphilic Diarylethene Assembly
   Y. Kotani, H. Yasuda, K. Higashiguchi*, K. Matsuda*
   Chem. Eur. J. 2021, 27(43), 11158-11166. (2021.5)
   Doi: 10.1002/chem.202101127
8. Origin of aggregation-induced enhanced emission: role of pseudo-degenerate electronic states of excimers formed in aggregation phases
   W. Ota, K. Takahashi, K. Higashiguchi, K. Matsuda, T. Sato*
   J. Mater. Chem. C 2020, 8(24), 8036-8046. (2020.5)
   Doi: 10.1039/D0RA04484A
9. A Diarylethene Annulated Isomer as a Highly-Conductive Molecular Wire Evaluated by the Exchange Interaction between Two Nitroxides
   Y. Sumiya, K. Higashiguchi, K. Matsuda*
   Chem. Commun. 2020, 56(16), 2447-2450. (2020.1)
   Doi: 10.1039/C9CC10017B
10. Inorganic–Organic Hybrid Photomechanical Crystals Consisting of Diarylethenes and Cage Siloxanes
    R. Kajiya, S. Sakakibara, H. Ikawa, K. Higashiguchi*, K. Matsuda, H. Wada, K. Kuroda, A. Shimojima*
    Chem. Mater. 2019, 31(22), 9372−9378. (2019.11)
    Doi: 10.1021/acs.chemmater.9b02941
11. Photoinduced Repetitive Separation of the Supramolecular Assembly composed of Amphiphilic Diarylethene Mixture
    S. Sakakibara, H. Yotsuji, K. Higashiguchi*, K. Matsuda*
    Soft Matter 2019, 15(39), 7918−7925. (2019.9)
    Doi: 10.1039/C9SM01301F
12. Photocontrollable ambipolar transistors with π-conjugated diarylethene photochromic channels
    Y. Kurokawa, R. Hayakawa,* S. Shimada, K. Tanaka, K. Higashiguchi, Y. Noguchi, K. Matsuda,* Y. Wakayama*
    Jpn. J. Appl. Phys. 2019, 58, SDDH03 (2019.1)
    Doi: 10.7567/1347-4065/ab09ce
13. Ambipolar Carrier Transport in an Optically Controllable Diarylethene Thin Film Transistor
    Y. Kurokawa, R. Hayakawa,* S. Shimada, K. Higashiguchi, Y. Noguchi, K. Matsuda,* Y. Wakayama*
    Org. Electron. 2019, 64, 205−208. (2018.9)
    Doi: 10.1016/j.orgel.2018.10.020
14. Structural Colored Balloon Composed of Temperature-Responsive Polymers Showing LCST Behavior
    K. Higashiguchi,* N. Morita, K. Matsuda*
    Langmuir 2018, 34(43), 12853−12860. (2018.9)
    Doi: 10.1021/acs.langmuir.8b02002
15. Bundle Formation of Supramolecular Fibers of Amphiphilic Diarylethene by Depletion Force
    A. Sakaguchi, K. Higashiguchi,* K. Matsuda*
    Chem. Commun. 2018, 54(34), 4298−4301. (2018.3)
    Doi: 10.1039/C8CC01666F
16. Determination of Quantum Yield of Photoreaction in Solution and in Suspension by Global Fitting of Prolonged Change of Concentration
    K. Higashiguchi, H. Yotsuji, K. Matsuda*
    Chem. Lett. 2017, 46(10), 1564−1566. (2017.8)
    Doi: 10.1246/cl.170673
17. Anisotropic Diffusion of Microbeads Surrounded by an Anisotropically Elongated Supramolecular Diarylethene Architecture under Linearly Polarized Light
    A. Sakaguchi, K. Higashiguchi,* K. Matsuda*
    ChemPhotoChem 2017, 1(11), 488−492. (2017.7)
    Doi: 10.1002/cptc.201700101
18. Phototransformative Supramolecular Assembly of Amphiphilic Diarylethenes Realized by the Combination of Photochromism and Lower Critical Solution Temperature Behavior
    H. Yotsuji, K. Higashiguchi,* R. Sato, Y. Shigeta, K. Matsuda*
    Chem. Eur. J 2017, 23(60), 15059−15066. (2017.7)
    Doi: 10.1002/chem.201702202
19. Photocontrol of Clustering, Retaining, and Releasing of Microbeads Concomitant with Phototransformation of Supramolecular Architecture of Amphiphilic Diarylethene
    A. Sakaguchi, K. Higashiguchi,* H. Yotsuji, K. Matsuda*
    J. Phys. Chem. B 2017, 121(16), 4265−4272. (2017.3)
    Doi: 10.1021/acs.jpcb.7b00901
20. Laser Patterning of Optically Reconfigurable Transistor Channels in a Photochromic Diarylethene Layer
    T. Tsuruoka,* R. Hayakawa, K. Kobashi, K. Higashiguchi, K. Matsuda,* Y. Wakayama*
    Nano Lett. 2016, 16(12), 7474–7480. (2016.11)
    Doi: 10.1021/acs.nanolett.6b03162
21. Two-Photon Cycloreversion Reaction of Diarylethene on Gold Nanotriangles
    K. Higashiguchi, M. Nakazaki, K. Matsuda*
    Adv. Opt. Mater. 2016, 4(9), 1385–1391. (2016.6)
    Doi: 10.1002/adom.201600172
22. Photoswitching of Conductance of Diarylethene–Gold Nanoparticle Network Based on the Alteration of π-Conjugation
    T. Toyama, K. Higashiguchi, T. Nakamura, H. Yamaguchi, E. Kusaka, K. Matsuda*
    J. Phys. Chem. Lett. 2016, 7(11), 2113–2118. (2016.5)
    Doi: 10.1021/acs.jpclett.6b00993
23. Structural Colored Balloons Responsive to pH change
    K. Higashiguchi*, J. Imai, K. Matsuda*
    Langmuir 2016, 32(19), 4945–4951. (2016.4)
    Doi: 10.1021/acs.langmuir.6b00607
24. DNA Microenvironment Monitored by Controlling Redox Blinking
    K. Kawai*, K. Higashiguchi, A. Maruyama, T. Majima
    ChemPhysChem 2015, 16(17), 3590–3594. (2015.9)
    Doi: 10.1002/cphc.201500793
25. Giant Polymer Lattice in a Polymer-stabilized Blue Phase Liquid Crystal
    H. Kikuchi*, S. Izena, H. Higuchi, Y. Okumura, K. Higashiguchi
    Soft Matter 2015, 11(23), 4572-4575. (2015.4)
    Doi: 10.1039/C5SM00711A
26. Interface Engineering for Improving Optical Switching in a Diarylethene-Channel Transistor
    R. Hayakawa, M. Petit, K. Higashiguchi, K. Matsuda,* T. Chikyow, Y. Wakayama*
    Org. Electron. 2015, 21, 149-154. (2015.3)
    Doi: 10.1016/j.orgel.2015.03.011
27. Photoinduced Macroscopic Morphological Transformation of an Amphiphilic Diarylethene Assembly: Reversible Dynamic Motion
    K. Higashiguchi*, G. Taira, J.-i. Kitai, T. Hirose, K. Matsuda*
    J. Am. Chem. Soc. 2015, 137(7), 2722−2729. (2015.2)
    Doi: 10.1021/ja512924q
28. The Effect of Cyano Substitution on Fluorescence Behavior of 1,2-Bis(pyridylphenyl)ethene
    S. Nishio, K. Higashiguchi, K. Matsuda*
    Asian J. Org. Chem. 2014, 3(6), 686–690. (2014.3)
    Doi: 10.1002/ajoc.201402024
29. An Investigation on CD Inversion at Visible Region Caused by a Tilt of π-Conjugated Substituent: Theoretical and Experimental Approaches by Using Asymmetric Framework of Diarylethene Annulated Isomer
    T. Hirose, Y. Inoue, J.-y. Hasegawa, K. Higashiguchi, K. Matsuda*
    J. Phys. Chem. A 2014, 118(6), 1084–1093. (2014.1)
    Doi: 10.1021/jp4122694
30. Photoisomerization–induced Manipulation of Single-Electron Tunneling for Novel Si-based Optical Memory
    R. Hayakawa, K. Higashiguchi, K. Matsuda, T. Chikyow, Y. Wakayama*
    ACS Appl. Mater. Interfaces 2013, 5(21), 11371–11376. (2013.10)
    Doi: 10.1021/am403616m
31. Evaluation of β Value of Phenylene Ethynylene Unit by Probing Exchange Interaction between Two Nitronyl Nitroxides
    M. Shinomiya, K. Higashiguchi, K. Matsuda*
    J. Org. Chem. 2013, 78(18), 9282-9290. (2013.8)
    Doi: 10.1021/jo4015062
32. Photocontrol of Solvent Responsiveness of Structural Colored Balloons
    M. Inoue, K. Higashiguchi*, K. Matsuda*
    Langmuir 2013, 29(23), 7047–7051. (2013.5)
    Doi: 10.1021/la400534s
33. Optically- and electrically-driven organic thin film transistors with diarylethene photochromic channel layers
    R. Hayakawa, K. Higashiguchi, K. Matsuda,* T. Chikyow, Y. Wakayama*
    ACS Appl. Mater. Interfaces 2013, 5(9), 3625–3630. (2013.4)
    Doi: 10.1021/am400030z
34. Spatial Distribution Control of Polymer Nanoparticles by Liquid Crystal Disclinations
    K. Higashiguchi, K. Yasui, M. Ozawa, K. Odoi, H. Kikuchi*
    Polymer J. 2012, 44(6), 632–638. (2012.4)
    Doi: 10.1038/pj.2012.44
35. Solvent-Responsive Structural Colored Balloons
    K. Higashiguchi*, M. Inoue, T. Oda, K. Matsuda*
    Langmuir 2012, 28(12), 5432-5437. (2012.3)
    Doi: 10.1021/la3006234
36. Chronological Change from Face-On to Edge-On Ordering of Zinc Tetraphenylporphyrin at Phenyloctane-HOPG Interface
    T. Sakano, J.-y. Hasegawa, K. Higashiguchi, K. Matsuda*
    Chem. Asian J. 2012, 7(2), 394-399. (2012.2)
    Doi: 10.1002/asia.201100587
37. Comparison of Molecular Conductance between Planar and Twisted 4-Phenylpyridines by Means of Two-Dimensional Phase Separation of Tetraphenylporphyrin Templates at a Liquid-HOPG Interface
    T. Sakano, K. Higashiguchi, K. Matsuda*
    Chem. Commun. 2011, 47(29), 8427-8429. (2011.8)
    Doi: 10.1039/c1cc12041g
38. π-Conjugation of Two Nitronyl Nitroxides-Attached Diarylethenes
    S. Yokojima, T. Kobayashi, K. Shinoda, K. Matsuda, K. Higashiguchi, S. Nakamura*
    J. Phys. Chem. B 2011, 115(18), 5685-5692. (2011.4)
    Doi: 10.1021/jp2002707
39. Self-Assembly and Aggregate-Induced Enhanced Emission of Amphiphilic Fluorescence Dyes in Water and in the Solid State
    T. Hirose, K. Higashiguchi, K. Matsuda*
    Chem. Asian J. 2011, 6(4), 1057-1063. (2011.4)
    Doi: 10.1002/asia.201000824
40. Evaluation of the β Value of the Phenylene Unit by Probing Exchange Interaction between Two Nitroxides
    K. Higashiguchi, K. Yumoto, K. Matsuda*
    Org. Lett. 2010, 12(22), 5284-5286. (2010.11)
    Doi: 10.1021/ol102339m
41. Direct Observation of Polymer-Stabilized Blue Phase I Structure with Confocal Laser Scanning Microscope
    K. Higashiguchi, K. Yasui, H. Kikuchi*
    J. Am. Chem. Soc. 2008, 130(20), 6326-6327. (2008.4)
    Doi: 10.1021/ja801553g
42. Full-Color Photochromism of a Fused Dithienylethene Trimer
    K. Higashiguchi, K. Matsuda,* N. Tanifuji, and M. Irie*
    J. Am. Chem. Soc. 2005, 127(25), 8922-8923. (2005.6)
    Doi: 10.1021/ja051467i
43. Photochromism of Dithienylethenes Having Fluorinated Thiophene Rings
    K. Higashiguchi, K. Matsuda, Y. Asano, A. Murakami, S. Nakamura, and M. Irie*
    Eur. J. Org. Chem. 2005, (1), 91-97. (2005.1)
    Doi: 10.1002/ejoc.200400441
44. Crystal to crystal transformation in the solid state
    R. Kuroda*, K. Higashiguchi, S. Hasebe, and Y. Imai
    CrystEngComm 2004, 6(76), 464-469. (2004.9)
    Doi: 10.1039/b408971e
45. Photochromic Reaction of a Fused Dithienylethene: Multicolor Photochromism
    K. Higashiguchi, K. Matsuda, and M. Irie*
    Angew. Chem. Int. Ed. 2003, 42(30), 3537-3540. (2003.8)
    Doi: 10.1002/anie.200351751
46. Reversed Photoswitching of Intramolecular Magnetic Interaction Using A Photochromic Bis(2-thienyl)ethene Spin Coupler
    K. Matsuda,* M. Matsuo, S. Mizoguti, K. Higashiguchi, and M. Irie*
    J. Phys. Chem. B 2002, 106(43), 11218-11225. (2002.10)
    Doi: 10.1021/jp026562h
47. Photochromic Reactivity of a Dithienylethene Dimer
    K. Higashiguchi, K. Matsuda, M. Matsuo, T. Yamada, and M. Irie*
    J. Photochem. Photobiol., A 2002, 152(1-3), 141-146. (2002.9)
    Doi: 10.1016/S1010-6030(02)00232-0
48. Fatigue Mechanism of Photochromic 1,2-Bis(3-thienyl)perfluorocyclopentene
    K. Higashiguchi, K. Matsuda, T. Yamada, T. Kawai, and M. Irie*
    Chem. Lett. 2000, (12), 1358-1359. (2000.12)
    Doi: 10.1246/cl.2000.1358
49. Fatigue Mechanism of Photochromic 1,2-Bis(2,5-dimethyl-3- thienyl)perfluoro-cyclopentene
    K. Higashiguchi, K. Matsuda, S. Kobatake, T. Yamada, T. Kawai, and M. Irie*
    Bull. Chem. Soc. Jpn. 2000, 73(10), 2389-2394. (2000.10)
    Doi: 10.1246/bcsj.73.2389

レビュー・記事

1. 松田建児、東口顕士
   “フォトクロミック分子を用いた発動分子システム”
   現代化学, 2021, 2, 36-39. (2021.1)
   
2. K. Higashiguchi, K. Matsuda
   “Photoinduced Morphological Transformation and Photodriven Movement of Objects Using Self-assembly of Amphiphilic Diarylethene in Water”
   in "Photosynergetic Responses in Molecules and Molecular Aggregates", H. Miyasaka, K. Matsuda, J. Abe, T. Kawai eds.,
   2020, 327-348, Springer, Singapore. (2020.9)
   
3. Photochromism for optically functionalized organic field-effect transistors: a comprehensive review
   Y. Wakayama, R. Hayakawa, K. Higashiguchi, K. Matsuda
   J. Mater. Chem. C 2020, 8(32), 10956-10974 (2020.7)
   Doi: 10.1039/D0TC02683B
4. 東口顕士、松田建児
   “両親媒性ジアリールエテン会合体の光誘起LCST転移挙動：光変形する超分子構造体と光による物体移動”
   有機合成化学協会誌, 2019, 77(3), 236-245. (2019.3)
   
5. Y. Kageyama, Y. Takenaka, and K. Higashiguchi
   Chapter 8 "Material Transfer and Spontaneous Motion in Mesoscopic Scale with Molecular Technology"
   in Molecular Technology: Energy Innovation, H. Yamamoto and T. Kato ed., Wiley-VCH. 187-208 (2018.9)
6. 菊池裕嗣、樋口博紀、奥村泰志、東口顕士
   “液晶のトポロジカル欠陥と高分子の相互作用”
   高分子, 2015, 64(11), 721-726. (2015.11)
7. 東口顕士
   “構造色バルーンの溶媒応答性および光制御”
   ナノ・マイクロカプセル(状粒子)の調製・評価・応用≪検討例集≫，技術情報協会. (2014.10)
8. 東口顕士
   “超分子構造体の光誘起形態変化と光駆動物質輸送”
   第2次先端ウオッチング調査「社会の持続的発展のための分子技術」，日本化学会. (2014.3)
9. 東口顕士
   “マイクロビーズを直線配列させる”
   化学，2013, 68, (5), 67-68. (2013.5)
10. 東口顕士、松田建児
    “ジアリールエテンと金属ナノ粒子による光分子エレクトロニクス材料”
    「フォトクロミズムの新展開と光メカニカル機能材料」，シーエムシー出版，96-101.
11. K. Matsuda, K. Higashiguchi
    Photoswitching Property of Diarylethenes in Molecular Magnetism and Electronics
    in Supramolecular Soft Matter: Applications in Materials and Organic Electronics,
    T. Nakanishi ed., Wiley, Hoboken, NJ, pp. 215-236.
12. 東口顕士、松田建児
    “有機機能分子と光分子エレクトロニクス”
    ケミカルエンジニアリング, 2009, 54(1), 13-17. (2009.1)

依頼・招待講演

1. ”光誘起変形を示す水分散超分子構造体の運動”
   化学工学会 第51回秋季大会
   オンライン、2020.9
2. ”Phototransformative Supramolecular Assembly of Amphiphilic Diarylethenes”
   PPSM, ENS Paris-Saclay
   フランス、2020.1
3. ”ジアリールエテン超分子構造体の光誘起形態変化と光駆動運動”
   第40回光化学若手の会
   東京、2019.6
4. ”ジアリールエテン超分子構造体の形態変化の制御および物体移動”
   第38回光化学若手の会
   福岡、2017.6
5. ”ジアリールエテン超分子構造体に関する研究”
   第37回光化学若手の会
   大阪、2016.6
6. ”構造色バルーンの溶媒応答性および光制御”
   第35回光化学若手の会
   福岡、2014.6
7. ”超分子構造体の光誘起形態変化と光駆動物質輸送”
   日本化学会春期年会 イブニングセッション
   愛知、2014.3
8. ”Photocontrol of Solvent-Responsive Structural Colored Balloons”
   International Sympoium on Green Photonics for Efficient: Photon-Harvesting Materials and Reactions (ISGP 2014)
   奈良、2014.2
9. ”Solvent-Responsive Structural Colored Balloons”
   The 3rd International Kyoto Symposium on Organic Nanostructures
   京都、2013.11
10. ”ジアリールエテン超分子構造体の光誘起形態変化”
    2013年光化学討論会
    愛媛、2013.9
11. ”可変性のある発色について”
    新学術領域「融合マテリアル」第５回若手スクール
    鳥取、2012.11
12. ”構造色バルーンの溶媒応答性および光応答性”
    第61回高分子討論会
    愛知、2012.9
13. “ニトロキシド間の交換相互作用の測定によるフェニレンユニットのβ値の評価”
    「単分子エレクトロニクスの現状認識と近未来実現へ向けての中核体制構築」研究会
    京都、2012.2
14. ”ジアリールエテンのフルカラーフォトクロミズム”
    第31回光化学若手の会
    京都、2009.6

特許

1. 若山裕、鶴岡徹、早川竜馬、松田建児、東口顕士
   “有機トランジスタとその動作制御方法および動作制御装置”
   特願2016-184292　特開2018-049931　特許6804082（成立特許）
2. 菊池裕嗣、東口顕士、安井圭、小澤雅昭、大土井啓祐
   “コアシェル型分岐状高分子からなる蛍光性プローブ”
   特願2008-194820　特開2010-31144　特許5590538（成立特許）