Selected Publications

2013
Kozai D, Kabasawa Y, Ebert M, Kiyonaka S, Man F, Otani Y, Numata T, Takahashi N, Mori Y & Ohwada T
Trans-nitrosylation Directs TRPA1 Selectivity in N-Nitrosamine Activators.
Mol Pharmacol. in press
2013
Kiyonaka S, Kajimoto T, Sakaguchi R, Shinmi D, Omatsu-Kanbe M, Matsuura H, Imamura H, Yoshizaki T, Hamachi I, Morii T, & Mori Y. Genetically encoded fluorescent thermo-sensors for visualizing subcellular thermoregulation in living cells. Nat Methods10, 1232-1238 (2013)
2012
Tadmouri A, Kiyonaka S, Barbado M, Rousset M, Fablet K, Sawamura S, Bahembera E, Pernet-Gallay K, Arnoult C, Miki T, Sadoul K, Gory-Faure S, Lambrecht C, Lesage F, Akiyama S, Khochbin S, Baulande S, Janssens V, Andrieux A, Dolmetsch R, Ronjat M, Mori Y, De Waard M. Cacb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy. EMBO J. 31(18), 3730-44 (2012).
2011
Takahashi N, Kuwaki K, Kiyonaka S, Numata T, Kozai D, Mizuno Y, Yamamoto S, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J & Mori Y. TRPA1 underlies a sensing mechanism for O2. Nature Chem. Biol. 7, 701-711 (2011).
2009
Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, Sawaguchi Y, Yoshida T, Wakamori M, Mori E, Numata T, Ishii M, Takemoto H, Ojida A, Watanabe K, Uemura A, Kurose H, Morii T, Kobayashi T, Sato Y, Sato C, Hamachi I & Mori Y. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.Proc. Natl. Acad. Sci. USA 106, 5400-5405 (2009).
2008
Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H & Mori Y. TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nature Med. 14, 738-747 (2008).
2007
Kiyonaka S, Wakamori M, Miki T, Uriu Y, Nonaka M, Bito H, Beedle AM, Mori E, Hara Y, De Waard M, Kanagawa M, Itakura M, Takahashi M, Campbell KP & Mori Y. RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nature Neurosci. 10, 691-701 (2007).
2006
Yoshida T, Inoue R, Morii T, Takahashi N, Yamamoto S, Hara Y, Tominaga M, Shimizu S, Sato Y & Mori Y. Nitric oxide activates TRP channels by cysteine S-nitrosylation.Nature Chem. Biol. 2, 596-607 (2006).
2002
Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, ShimizuS, Mori E, Kudoh J, ShimizuN, KuroseH, OkadaY, ImotoK & Mori Y. LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol. Cell 9, 163-173 (2002).
1991
Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki K, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K & Mori Y. Molecular and functional characterization of a novel mouse TRP homologue TRP7: Ca2+ permeable cation channel that is constitutively activated and enhanced by stimulation of G-protein-coupled receptor. J. Biol. Chem. 274, 27359-27370 (1999).
1998
Okada T, Shimizu S, Wakamori M, Maeda A, Kurosaki K, Takada N, Imoto K & Mori Y. Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J. Biol. Chem. 273, 10279-10287 (1998).
1994
Pragnell M, Waard MD, Mori Y, Tanabe T, Snutch TP & Campbell K. Calcium channel b-subunit binds to a conserved motif in the I-II cytoplasmic linker of the a1 subunit. Nature 368, 67-70 (1994).
1991
Mori Y, Friedrich T, Kim M-S, Mikami A, Nakai J, Ruth P, Bosse E, Hofmann F, FlockerziV, Furuichi T, Mikoshiba K, ImotoK, Tanabe T & Numa S. Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature 350, 398-402 (1991).
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