Welcome to the Laboratory of Molecular Biology of the Kyoto University

Calcium ion (Ca2+) is a second messenger involved in various physiological phenomena. In contrast to the high Ca2+ concentration (2 mM) in the extracellular fluid, cells maintain the cytosolic Ca2+ at nM concentration. However, in the presence of external stimuli, the cytosolic Ca2+ concentration increase about hundred fold through the activation of calcium channels on the plasmamembrane and triggers a diverse array of physiological response. In order to delineate the physiological significance of these calcium channels, our laboratory study voltage dependent calcium channels (VDCCs) and transient receptor potential (TRP) channels at various levels of an organism using molecular, cellular and physiological techniques.

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