Assistant professor　　　窪田 亮　- Ryou Kubota - †

Paper List †

Article †

28. Emergence of dynamic instability by hybridizing synthetic self-assembled dipeptide fibers with surfactant micelles.
Shogo Torigoe, Kazutoshi Nagao, Ryou Kubota*, Itaru Hamachi*
Journal of the American Chemical Society, 146, 9, 5799–5805 (2024)　doi: 10.1021/jacs.3c14565

27. Visualizing formation and dynamics of a three-dimensional sponge-like network of a coacervate in real time.
Ryou Kubota*, Taro Hiroi, Yuriki Ikuta, Yuchong Liu, Itaru Hamachi*
Journal of the American Chemical Society, 145, 33, 18316-18328 (2023) doi:10.1021/jacs.3c03793

26. Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions.
Keisuke Nakamura, Ryou Kubota*, Takuma Aoyama, Kenji Urayama, Itaru Hamachi*
Nature Communications, 14: 1696 (2023)　doi:10.1038/s41467-023-37412-0

25. Temporal stimulus patterns drive differentiation of a synthetic dipeptide-based coacervate.
Ryou Kubota*, Shogo Torigoe, Itaru Hamachi*
Journal of the American Chemical Society, 144, 33, 15155-15164 (2022) doi:10.1021/jacs.2c05101

24. Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue.
Kento Ojima, Wataru Kakegawa, Tokiwa Yamasaki, Yuta Miura, Masayuki Itoh, Yukiko Michibata, Ryou Kubota, Tomohiro Doura, Eriko Miura, Hiroshi Nonaka, Seiya Mizuno, Satoru Takahashi, Michisuke Yuzaki*, Itaru Hamachi*, Shigeki Kiyonaka*
Nature Communications, [Paper #NCOMMS-21-40284B] (2022) Just Accepted

23. Shape-selective One-step Synthesis of Branched Gold Nanoparticles on the Crystal Surface of Redox-active PdII Macrocycles.
Yutaro Yamashita, Shohei Tashiro, Yoshiki Ishii, Takayuki Uchihashi, Nobuyuki Matsushita, Ryou Kubota, Mitsuhiko Shionoya
Dalton Transactions, 51,1318–1324 (2022)　doi: 10.1039/d1dt03973c

22. Photo-triggered spatially controlled out-of-equilibrium patterns of peptide nanofibers in a self-sorting double network hydrogel.
Keisuke Nakamura, Wataru Tanaka, Kei Sada, Ryou Kubota, Takuma Aoyama, Kenji Urayama, Itaru Hamachi
Journal of the American Chemical Society, 143, 46, 19532–19541(2021)　doi:10.1021/jacs.1c09172

21. Face-selective adsorption of a prochiral compound on the chiral pore-surface of metal-macrocycle framework (MMF) directed towards stereoselective reactions.
Shohei Tashiro, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya
Faraday Discuss225, 197–209 (2021) 　doi:10.1039/D0FD00019A

20. In Situ Real-time Confocal Imaging of a Self-assembling Peptide-grafted Polymer Showing pH-responsive Hydrogelation.
Ryou Kubota, Shogo Torigoe, Shuang Liu, & Itaru Hamachi*
Chemistry Letters, 49, 11, 1319-1323 (2020)　doi:10.1246/cl.200513

19. Control of seed formation allows two distinct self-sorting patterns of supramolecular nanofibers.
Ryou Kubota, Kazutoshi Nagao, Wataru Tanaka, Ryotaro Matumura, Takuma Aoyama, Kenji Urayama and Itaru Hamachi*
Nature Communications, 11: 4100 (2020)　doi:10.1038/s41467-020-17984-x

18. Protein-Responsive Protein-Release of Supramolecular/polymer Hydrogel Composite Integrating Enzyme Activation Systems.
Hajime Shigemitsu, Ryou Kubota, Keisuke Nakamura, Tomonobu Matsuzaki, Saori Minami, Takuma Aoyama, Kenji Urayama and Itaru Hamachi*
Nature Communications, 11: 3859 (2020)　doi:10.1038/s41467-020-17698-0

17. Force generation by a propagating wave of supramolecular nanofibers.
Ryou Kubota, Masahiro Makuta, Ryo Suzuki, Masatoshi Ichikawa, Motomu Tanaka and Itaru Hamachi*
Nature Communications, 11: 3541 (2020)　doi:10.1038/s41467-020-17394-z

16. Core-shell metal-macrocycle framework (MMF): spatially selective dye inclusion through core-to-shell anisotropic transport along crystalline 1D-channels connected by epitaxial growth.
Shohei Tashiro, Shinya Mitsui, David W. Burke, Ryou Kubota, Nobuyuki Matsushita, Mitsuhiko Shionoya
CrystEngComm, 22, 1306–1309 (2020)　doi:10.1039/D0CE00120A

15. pH Nanosensor Using Electronic Spins in Diamond.
Takahiro Fujisaku, Ryotaro Tanabe, Shinobu Onoda, Ryou Kubota, Takuya F. Segawa, Frederick T.-K. So, Takeshi Ohshima, Itaru Hamachi, Masahiro Shirakawa, Ryuji Igarashi*
ACS Nano, 13, 10, 11726-11732 (2019)　doi:10.1021/acsnano.9b05342

14. Post-assembly fabrication of a functional multicomponent supramolecular hydrogel based on a self-sorting double network.
Wataru Tanaka, Hajime Shigemitsu, Takahiro Fujisaku, Ryou Kubota, Saori Minami, Kenji Urayama, Itaru Hamachi
Journal of the American Chemical Society, 141, 12, 4997–5004 (2019)　doi: 10.1021/jacs.9b00715

13. Rational synthesis of benzimidazole[3]arenes by Cu-II-catalyzed post-macrocyclization transformation.
Shohei Tashiro*, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya*
Chemical Science, 9, 7614–7619 (2018)　doi:10.1039/C8SC03086C

12. Chemogenetic Approach Using Ni(II) Complex–Agonist Conjugates Allows Selective Activation of Class A G-Protein-Coupled Receptors.
Ryou Kubota, Wataru Nomura, Takuma Iwasaka, Kento Ojima, Shigeki Kiyonaka, Itaru Hamachi
ACS Central Science, 4, 9, 1211–1221 (2018)

11. Imaging-based study on control factors over self-sorting of supramolecular nanofibers formed from peptide- and lipid-type hydrogelators.
Ryou Kubota, Shuang Liu, Hajime Shigemitsu, Keisuke Nakamura, Wataru Tanaka, Masato Ikeda, Itaru Hamachi
Bioconjugate Chemistry, 29, 6, 2058–2067 (2018)

10. An adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks.
Hajime Shigemitsu, Takahiro Fujisaku, Wataru Tanaka, Ryou Kubota, Saori Minami, Kenji Urayama, Itaru Hamachi
Nature Nanotechnology, 13, 165-172 (2018)

9. Non-covalent immobilisation of p-toluenesulfonic acid in a porous molecular crystal for size-specific acid-catalysed reactions.
Shohei Tashiro, Hirotaka Yonezawa, Ryou Kubota, Tsutomu Umek,i Mitsuhiko Shionoya
Chem. Commun., 52, 7657-7660 (2016).

8. Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells.
Shigeki Kiyonaka, Ryou Kubota, Yukiko Michibata, Masayoshi Sakakura, Hideo Takahashi, Tomohiro Numata, Ryuji Inoue, Michisuke Yuzaki, Itaru Hamachi
Nat. Chem., 8, 958–967(2016).

7. In situ real-time imaging of self-sorted supramolecular nanofibres.
Shoji Onogi, Hajime Shigemitsu, Tatsuyuki Yoshii, Tatsuya Tanida, Masato Ikeda, Ryou Kubota, Itaru Hamachi
Nat. Chem., 8, 743-752 (2016).

6. Chiral Metal–macrocycle Frameworks: Supramolecular Chirality Induction and Helicity Inversion of the Helical Macrocyclic Structures.
Ryou Kubota, Shohei Tashiro, Mitsuhiko Shionoya
Chem. Sci., 7, 2217-2221 (2016).

5. In situ X-ray Snapshot Analysis of Transient Molecular Adsorption in a Crystalline Channel.
Ryou Kubota, Shohei Tashiro, Motoo Shiro, Mitsuhiko Shionoya
Nature Chem., 6, 913–918 (2014).

4. Simultaneous Arrangement of up to Three Different Molecules on the Pore Surface of Metal-Macrocycle Framework (MMF): Cooperation and Competition.
Shohei Tashiro, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya
Angew. Chem. Int. Ed., 53, 8310–8315 (2014).

3. Palladium- or Proton-induced Submicro Spherical Aggregation of Macrocyclic Amphiphiles in Aqueous Solution.
Shohei Tashiro, Ryou Kubota, Minori Kawagoe, Mitsuhiko Shionoya
Dalton. Trans., 42, 15915–15918 (2013).

2. Non-Covalent Surface Modification of Metal-Macrocycle Framework with Mono-Substitutes Benzenes.
Ryou Kubota, Shohei Tashiro, Tsutomu Umeki, Mitsuhiko Shionoya
Supramol. Chem., 24, 867–877 (2012).

1. Metal–Macrocycle Framework (MMF): Supramolecular Nano-Channel Surfaces with Shape Sorting Capability.
Shohei Tashiro, Ryou Kubota, Mitsuhiko Shionoya
J. Am. Chem. Soc., 134, 2461–2464 (2012).

Review †

10. Supramolecular–Polymer Composite Hydrogels: From InSitu Network Observation to Functional Properties
Ryou Kubota
Bulletin of the Chemical Society of Japan, 96, 8, 724-841 (2023)　doi:10.1246/bcsj.20230129

9. Cell-Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non-/Out-of-Equilibrium Dynamic Systems
Ryou Kubota*, Itaru Hamachi*
Advanced Science, 2806830 (2023)　doi:10.1002/advs.202306830 open access

8. Microscopic Imaging Techniques for Molecular Assemblies: Electron, Atomic Force, and Confocal Microscopies
Ryou Kubota, Wataru Tanaka, Itaru Hamachi*
Chemical Reviews, 121, 22, 14281-14347 (2021)　 doi:10.1021/acs.chemrev.0c01334

7. The Power of Confocal Laser Scanning Microscopy in Supramolecular Chemistry: In situ Real‐time Imaging of Stimuli‐Responsive Multicomponent Supramolecular Hydrogels
Ryou Kubota, Keisuke Nakamura, Shogo Torigoe, Itaru Hamachi
ChemistryOPEN, 9,67-79 (2020)　doi: 10.1002/open.201900328

6. On-cell coordination chemistry: Chemogenetic activation of membrane-bound glutamate receptors in living cells.
Ryou Kubota, Shigeki Kiyonaka, Itaru Hamachi
Methods in Enzymology, 622, 411-430 (2019)　doi: 10.1016/bs.mie.2019.02.033

5. Molecular Technologies in Life Innovation:Novel Molecular Technologies for Labeling and Functional Control of Proteins Under Live Cell Conditions
Itaru Hamachi, Shigeki Kiyonaka, Tomonori Tamura, Ryou Kubota
Molecular Technology vol.2, 297-328 (2018)

4. グルタミン酸受容体の選択的活性化を可能とする錯体化学的アプローチ
窪田亮
生体機能関連化学部会 NEWS LETTER, 31, 3 (2016)

3. Protein Recognition with Synthetic Small-molecular Binders toward Optical Protein Sensing in Vitro and in Live Cells
Ryou Kubota, Itaru Hamachi
Chem. Soc. Rev., 44, 4454 - 4471 (2015)

2. 積み上げてつくる多孔性結晶：孤立空間と中空空間のインターフェースを制御する
田代省平、窪田亮、塩谷光彦
化学, 67, 64–65 (2012).

1. 非対称な壁面構造を有する単結晶ナノチャネルにおける位置選択的ゲスト分子吸着
窪田亮
Bull. Jpn. Soc. Coord. Chem., 57, 25–27 (2011).